Pathogenesis of corneal damage from pseudomonas exotoxin A.

نویسندگان

  • B H Iglewski
  • R P Burns
  • I K Gipson
چکیده

Pseudomonas aeruginosa exotoxin A was injected into rabbit corneas. Death of epithelial, endothelial, and stromal cells resulted, and necrosis of the cornea followed. Control eyes with exotoxin neutralized by specific antitoxin showed minimal damage. A dose-response pattern was evident. Antitoxin neutralization of pseudomonas exotoxin A in corneal ulcers may have possible therapeutic implications.

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عنوان ژورنال:
  • Investigative ophthalmology & visual science

دوره 16 1  شماره 

صفحات  -

تاریخ انتشار 1977